Safety

Safety information

Read this before starting any treatment. Share it with anyone who helps manage your care, and bring questions to your provider.

GLP-1 side effects and contraindications

Placeholder clinical summary. GLP-1 receptor agonists such as semaglutide and tirzepatide slow gastric emptying and change appetite signaling, which is also why most side effects are digestive. Report anything severe or persistent to your provider before your next dose.

Commonly reported side effects

Nausea, vomiting, or diarrhea, most often in the days after a dose increase
Constipation, bloating, reflux, or abdominal discomfort
Reduced appetite, fatigue, headache, or dizziness
Redness, itching, or swelling at the injection site
Low blood sugar, especially when combined with insulin or a sulfonylurea

Do not start if any apply

Personal or family history of medullary thyroid carcinoma
Multiple endocrine neoplasia syndrome type 2 (MEN 2)
Pregnancy, active attempts to conceive, or breastfeeding
Prior serious hypersensitivity reaction to a GLP-1 receptor agonist
History of pancreatitis, gastroparesis, or active severe gastrointestinal disease

Stop treatment and seek immediate care for severe or persistent abdominal pain, uncontrolled vomiting, signs of an allergic reaction, or sudden vision changes.

Before you start

Tell your provider about every medication, supplement, and condition you have, including diabetes, kidney or liver disease, and any history of eating disorders. Dose changes are gradual for a reason, so follow the titration schedule you are given.

Peptide treatments

Peptide protocols such as sermorelin, GHK-Cu, and glutathione are prescription products used under provider supervision. Evidence varies by peptide, and none of these formulations are FDA-approved for weight loss or anti-aging claims.

Compounded medications

Compounded products are prepared for an individual prescription and are not reviewed or approved by the FDA for safety or effectiveness. They are not interchangeable with brand-name products.

Storage and disposal

Follow the storage temperature printed on your label and use an approved sharps container for needles. Never share medication or devices with another person.

Emergencies

This service is not for emergencies. Call 911 or go to the nearest emergency department if you have severe symptoms.

This page is placeholder general information and does not replace the guidance of your licensed provider.